(R) -8- (3-Amino-piperidin-1-yl) -7-ariko-2-ynyl-3-metyl-1-

Linagliptin Linagliptin, yakozwe na Boehringer Ingelheim, yemejwe na FDA ku ya 2 Gicurasi 2011. Ikoreshwa mu guhuza imirire n'imyitozo ngororamubiri kugira ngo igabanye urugero rwa glucose mu maraso ku bantu barwaye diyabete yo mu bwoko bwa 2.Linagliptine itezimbere glucose yamaraso kubarwayi ibuza dipeptidyl peptidase-4 (DPP-4).

Incretin (Incretin) ifite ingaruka zo guteza imbere gusohora insuline na selile pancreatic islet B, cyane cyane harimo glucose iterwa na insulineotropique polypeptide (GIP) na glucagon isa na polypeptide-1 (GLP-1).DDP-4 ni protease ya serine iherereye hejuru ya selile.Ihuza poroteyine kandi igaragara cyane muri plasma no mu ngingo zitandukanye mu mubiri (nk'impyiko, umwijima, villi yo mu mara mato, selile endothelia, n'ibindi).Linagliptin ni inhibitori ya DPP-4 ibuza ibikorwa bya enzyme guhuza byimazeyo na DPP-4, gutinda kwangirika kwa GLP-1, kongera ibikorwa bya GLP-1, kandi bigatera imbaraga muburyo bwa glucose Insuline isohora kandi igabanya urwego rwa glucagon mu kuzenguruka, bityo igenga urwego glucose yamaraso yabarwayi barwaye diyabete yo mu bwoko bwa 2.

Ugereranije nizindi DPP-4 inhibitor, ibyiza byingenzi bya Linagliptin ni: bifite umutekano wimpyiko kandi birashobora kugabanya neza glycosilated hemoglobine.Linagliptin isohoka cyane mumyanda muburyo bwa prototype.Nyuma yubuyobozi bwo munwa, gusohora impyiko ni 5% gusa byamafaranga yatanzwe.Nubwo itangwa mu mitsi, 30.8% gusa irasohoka ikoresheje impyiko.Kubwibyo, ntabwo hakenewe abarwayi barimo kwivuza.Buri gihe ugenzure imikorere yumwijima nimpyiko no guhindura ibipimo.Abarwayi bose barashobora gukosora icyarimwe igipimo cyoroshye.
Ingaruka mbi ziterwa na Linagliptin ni indwara zifata imyanya y'ubuhumekero, kunanuka mu mazuru, kubabara imitsi, kubabara umutwe no kubabara mu muhogo.