• NEBANNER

(R) -8- (3-Amino-piperidin-1-yl) -7-ariko-2-ynyl-3-metyl-1-

(R) -8- (3-Amino-piperidin-1-yl) -7-ariko-2-ynyl-3-metyl-1-

Ibisobanuro bigufi:

Inzira ya molekulari: C25H28N8O2

Uburemere bwa molekile:472.54

CAS no:668270-12-0


Ibicuruzwa birambuye

Ibicuruzwa

Gusaba

Linagliptin Linagliptin, yakozwe na Boehringer Ingelheim, yemejwe na FDA ku ya 2 Gicurasi 2011. Ikoreshwa mu guhuza imirire n'imyitozo ngororamubiri kugira ngo igabanye urugero rwa glucose mu maraso ku bantu barwaye diyabete yo mu bwoko bwa 2.Linagliptine itezimbere glucose yamaraso kubarwayi ibuza dipeptidyl peptidase-4 (DPP-4).

Incretin (Incretin) ifite ingaruka zo guteza imbere gusohora insuline na selile pancreatic islet B, cyane cyane harimo glucose iterwa na insulineotropique polypeptide (GIP) na glucagon isa na polypeptide-1 (GLP-1).DDP-4 ni protease ya serine iherereye hejuru ya selile.Ihuza poroteyine kandi igaragara cyane muri plasma no mu ngingo zitandukanye mu mubiri (nk'impyiko, umwijima, villi yo mu mara mato, selile endothelia, n'ibindi).Linagliptin ni inhibitori ya DPP-4 ibuza ibikorwa bya enzyme guhuza byimazeyo na DPP-4, gutinda kwangirika kwa GLP-1, kongera ibikorwa bya GLP-1, kandi bigatera imbaraga muburyo bwa glucose Insuline isohora kandi igabanya urwego rwa glucagon mu kuzenguruka, bityo igenga urwego glucose yamaraso yabarwayi barwaye diyabete yo mu bwoko bwa 2.

Ugereranije nizindi DPP-4 inhibitor, ibyiza byingenzi bya Linagliptin ni: bifite umutekano wimpyiko kandi birashobora kugabanya neza glycosilated hemoglobine.Linagliptin isohoka cyane mumyanda muburyo bwa prototype.Nyuma yubuyobozi bwo munwa, gusohora impyiko ni 5% gusa byamafaranga yatanzwe.Nubwo itangwa mu mitsi, 30.8% gusa irasohoka ikoresheje impyiko.Kubwibyo, ntabwo hakenewe abarwayi barimo kwivuza.Buri gihe ugenzure imikorere yumwijima nimpyiko no guhindura ibipimo.Abarwayi bose barashobora gukosora icyarimwe igipimo cyoroshye.
Ingaruka mbi ziterwa na Linagliptin ni indwara zifata imyanya y'ubuhumekero, kunanuka mu mazuru, kubabara imitsi, kubabara umutwe no kubabara mu muhogo.

Ubuyobozi bukuru:urwego rwumushinga
Suzuma:98-102%

Inyuma:Ifu yera n'umuhondo ifu ya kristaline
Ipaki:25kg / ingoma

Ibikoresho byahujwe n'umurongo

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Icyemezo

JIN DUN Ubuvuzi bufiteImpamyabumenyi ya ISO kandi yujuje ubuziranenge bwa GMP, yakoresheje inzobere mu kuvura ibiyobyabwenge mu gihugu no mu mahanga bifite uburambe bukomeye bwo kuyobora R&D ya sosiyete.

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d68590fe
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Ibyiza byo Kwivuza

TECHNOL OGY INYUNGU
Pressure Umuvuduko mwinshi Catalytic Hydrogenation.Umuvuduko mwinshi Hydrogenolysis reaction.Imyitwarire ya Cryogenic (<-78% C)
● Synthesis ya Aromatic Heterocyclic
Re reaction Kuvugurura
Res Igisubizo cya Chiral
Heck, Suzuki, Negishi, Sonogashira.Gignard

JIN DUN R&D

Ibikoresho

Laboratwari yacu ifite ibikoresho bitandukanye byo kugerageza no kugerageza, nka: NMR (Bruker 400M) 、 HPLC 、 chiral-HPLC 、 LC-MS 、 LC-MS / MS (API 4000) 、 IR 、 UV 、 GC 、 GC-MS, Chromatografiya, Microwave Synthesizer, Parallel Synthesizer, Calorimeter itandukanye (DSC), Electron Microscope ...

Itsinda R&D

Ubuvuzi bwa Jindun bufite itsinda ryabakozi ba R&D babigize umwuga, kandi bukoresha impuguke nyinshi zo mu gihugu ndetse n’amahanga mu kuvura ibiyobyabwenge kugira ngo ziyobore R&D, bigatuma synthesis yacu neza kandi neza.

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Kugabana Urubanza

Twafashije amasosiyete menshi yimiti yimiti yo murugo, nkaHansoh, Hengrui na Pharm ya HEC.Hano tuzerekana igice cyabo.

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Urubanza rwa Customzation Urubanza rwa mbere:

Cas No.: 110351-94-5

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Urubanza rwa Customzation Urubanza rwa kabiri:

Cas No.: 144848-24-8

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Urubanza rwa Customzation Urubanza rwa gatatu:

Cas No.: 200636-54-0

Uburyo bw'ubufatanye

1.Hindura abahuza bashya cyangwa APIs.Kimwe nkuko byavuzwe haruguru kugabana, abakiriya bafite ibyo bakeneye kuri Intermediates cyangwa APIs, kandi ntibashobora kubona ibicuruzwa bikenewe kumasoko, noneho turashobora gufasha Customize.

2.Gutunganya neza ibicuruzwa bishaje.Itsinda ryacu rizafasha mugutezimbere no kunoza umusaruro nkuwo inzira ya reaction ishaje, igiciro cyumusaruro ni kinini, kandi imikorere ni mike.Turashobora gutanga ibyangombwa byuzuye byo guhererekanya ikoranabuhanga no kunoza imikorere, gufasha abakiriya kubyara umusaruro mwiza.

Kuva ibiyobyabwenge byibasiye INDs, JIN DUN Medical iraguhaumurongo umwe wihariye R&D ibisubizo.

JIN DUN Ubuvuzi bushimangira gushinga itsinda rifite inzozi, gukora ibicuruzwa byiyubashye, byitondewe, bikomeye, kandi byose kugirango ube umufatanyabikorwa wizewe ninshuti yabakiriya!


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