4- [4 - [(5S) -5- (Aminometero)
4- [4 - [(5S) -5- (Aminometero)
12. Hagati ya 4- (4-aminophenyl) -3-morpholinone (1) ya antivagulant rivaroxaban yateguwe nuburyo bubiri: romBromobenzene yagiye ikurikirana hamwe na Ethanolamine na chloroacetyl chloride kugirango ibone 4-benzene Morfoline irahita igabanuka kugirango igabanye kugabanuka 1, kandi umusaruro wose ni 32%;②Bromobenzene yabanje nitrate, hanyuma igakorwa na Ethanolamine kugirango ibone Ethanol 2- (4-nitroanilino), hanyuma igafungwa na chloroacetyl chloride.Kugabanya reaction itanga 1, kandi umusaruro wose ni 47%.
Rivaroxaban ni ubwoko bushya bwa anticoagulant ishobora gufatwa mu kanwa.Irabuza mu buryo butaziguye ibikorwa bya coagulation Xa, ifite ingaruka zirwanya anticoagulant, ntibisaba gukurikirana buri gihe, kandi ifite umutekano mwinshi.Hamwe nogukoresha kwa rivaroxaban, Ibisabwa kuri rivaroxaban bizagenda byiyongera buhoro buhoro.Izina ryimiti ya rivaroxaban ni 5-chloro-N - (((5S) -2-oxo-3- [4- (3-oxo- 4-morpholinyl) fenyl) -1,3-oxazolidine-5-yl) methyl -2-thiophenecarboxamide.Hano hari inzira ebyiri zubukorikori zavuzwe mubitabo, kandi inzira zombi zikoreshwa Hagati ya 4- (4-aminophenyl) -3-morpholinone.Nubwo hari raporo kuri synthesis ya 4- (4-aminophenyl) -3-morpholinone mugihugu ndetse no hanze yarwo, hariho igiciro kiri hejuru cyibikoresho fatizo bya reaction.Byinshi, bigoye kugura, cyangwa ibisabwa mubikorwa byo kubyitwaramo ni byinshi cyane, biragoye kubyumva, ntabwo bifasha kurengera ibidukikije nizindi mbogamizi, kandi ntabwo byujuje ibisabwa byumusaruro rusange winganda.Hindura uburyo bwingenzi hagati ya rivaroxaban 4- (4-aminophenyl) - Uburyo bwo gukora 3-morpholinone no kugabanya igiciro cyibikoresho fatizo bizamura rwose kuzamura no gukoresha rivaroxaban.Nta raporo yerekeye synthesis ya rivaroxaban mu Bushinwa.Turi kuri rivaroxaban Urufunguzo ruri hagati ya 4- (4-aminophenyl) -3-morpholinone inzira yubukorikori hamwe nikoranabuhanga byizwe muburyo bushya.Bromobenzene ebyiri na p-nitrobromobenzene nkibikoresho byo gutangiza birasabwa.Inzira.Wibande kuri cycleisation ya 3-morpholinone impeta.
Ubuyobozi bukuru:urwego rwumushinga
Inyuma:Ifu ya kirisiti yera
Ipaki:25kg / ingoma
suzuma （HPLC） Ibirimo birenze cyangwa bingana na 98.0%
JIN DUN Ubuvuzi bufiteImpamyabumenyi ya ISO kandi yujuje ubuziranenge bwa GMP, yakoresheje inzobere mu kuvura ibiyobyabwenge mu gihugu no mu mahanga bifite uburambe bukomeye bwo kuyobora R&D ya sosiyete.
TECHNOL OGY INYUNGU
Pressure Umuvuduko mwinshi Catalytic Hydrogenation.Umuvuduko mwinshi Hydrogenolysis reaction.Imyitwarire ya Cryogenic (<-78% C)
● Synthesis ya Aromatic Heterocyclic
Re reaction Kuvugurura
Res Igisubizo cya Chiral
Heck, Suzuki, Negishi, Sonogashira.Gignard
Ibikoresho
Laboratwari yacu ifite ibikoresho bitandukanye byo kugerageza no kugerageza, nka: NMR (Bruker 400M) 、 HPLC 、 chiral-HPLC 、 LC-MS 、 LC-MS / MS (API 4000) 、 IR 、 UV 、 GC 、 GC-MS, Chromatografiya, Microwave Synthesizer, Parallel Synthesizer, Calorimeter itandukanye (DSC), Electron Microscope ...
Itsinda R&D
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Urubanza rwa Customzation Urubanza rwa mbere:
Cas No.: 110351-94-5
Urubanza rwa Customzation Urubanza rwa kabiri:
Cas No.: 144848-24-8
Urubanza rwa Customzation Urubanza rwa gatatu:
Cas No.: 200636-54-0
1.Hindura abahuza bashya cyangwa APIs.Kimwe nkuko byavuzwe haruguru kugabana, abakiriya bafite ibyo bakeneye kuri Intermediates cyangwa APIs, kandi ntibashobora kubona ibicuruzwa bikenewe kumasoko, noneho turashobora gufasha Customize.
2.Gutunganya neza ibicuruzwa bishaje.Itsinda ryacu rizafasha mugutezimbere no kunoza umusaruro nkuwo inzira ya reaction ishaje, igiciro cyumusaruro ni kinini, kandi imikorere ni mike.Turashobora gutanga ibyangombwa byuzuye byo guhererekanya ikoranabuhanga no kunoza imikorere, gufasha abakiriya kubyara umusaruro mwiza.
Kuva ibiyobyabwenge byibasiye INDs, JIN DUN Medical iraguhaumurongo umwe wihariye R&D ibisubizo.
JIN DUN Ubuvuzi bushimangira gushinga itsinda rifite inzozi, gukora ibicuruzwa byiyubashye, byitondewe, bikomeye, kandi byose kugirango ube umufatanyabikorwa wizewe ninshuti yabakiriya!
![1,4′-Bipiperidine] -1′-karubone ya chloride HCl](http://cdn.globalso.com/jindunchem-med/21.png)
