2-butyl-5-nitro-3-benzofuranyl) [4- [3- (dibutylaMino) propoxy] phenyl]

Ikoreshwa mu mavuriro muri Hyperuricemia y'ibanze n'ayisumbuye, cyane cyane ku barwayi barwaye hyperuricemia, ndetse no ku barwayi bafite ikibazo cyo kubura impyiko, no ku barwayi bafite indwara ya goute isubiramo cyangwa idakira, ndetse no ku barwayi barwaye Hyperuricemia.Ikoreshwa mu barwayi barwaye Gouty nephropathie kugirango bagabanye ibimenyetso kandi bagabanye imiterere y'amabuye ya aside irike;amabuye ya gout;ikoreshwa muri uric aside impyiko n'indwara y'impyiko.

Umuti mushya wo kurwanya arititiki Atrial fibrillation (AF) ni indwara ishobora guhitana ubuzima.Bitewe no gusaza kw'abaturage, abantu ku isi hose impfu n'impfu ziterwa na fibrillation yo mu mubiri biriyongera, kandi bibaye ibibazo bishya by'ubuzima rusange.Muri Amerika hari abarwayi miliyoni 2.5 bafite fibrillation atriel na miliyoni 4.5 mu muryango w’ubumwe bw’ibihugu by’Uburayi.Nk’uko imibare ibigaragaza, ubwiyongere bwa fibrillation atriyale mu bantu barengeje imyaka 30 mu gihugu cyanjye ni 0,77%, ibyo bikaba byiyongera uko imyaka igenda ishira, naho abagabo bakaba hejuru y’abagore (0.9%: 0.7%).Indwara zitera fibrillation yo mu mubiri zirimo cyane cyane umuvuduko ukabije w'amaraso, indwara z'umutima zifata umutima, indwara z'umutima wa valvular, umutima utera ubwonko, ndetse no kunanirwa k'umutima.Ikimenyetso nyamukuru cy’abarwayi bafite fibrillation atriale ni umuvuduko udasanzwe wumuyaga, kandi kugenzura umuvuduko wumutima bifite umwanya runaka mubuvuzi bukabije no kubungabunga ibimenyetso.Amiodarone igira uruhare runini mukugenzura umuvuduko wumutima no kugarura injyana ya sinus, ariko ingaruka mbi zingingo zijyanye nintego zijyanye na iyode mu miterere yacyo zigabanya imikoreshereze y’amavuriro, nko kwangiza ibihaha, tiroyide, n’umwijima.Imyitwarire mibi yavuzwe haruguru nuburyo bwayo Iyode irimo ifitanye isano rya bugufi.Umuti mushya wa antarrhythmic Dronedarone (Dronedarone) wabonetse muguhindura imiterere ya amiodarone.Dronedarone ifite imiterere ya electrophysiologique isa na amiodarone, ariko ntabwo irimo iyode mu miterere yayo, bityo irashobora kwirinda ingaruka zikomeye zidasanzwe z'umutima zatewe na iyode ya Chemical.Dronedarone yemerewe gucuruzwa n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) muri Nyakanga 2009, kandi yemererwa kwamamaza mu muryango w’ubumwe bw’ibihugu by’Uburayi mu 2009. Ni n’umuti wa mbere mushya wa antarrhythmic wemejwe mu muryango w’ubumwe bw’ibihugu by’Uburayi mu myaka 10.Dronedarone ni N- [2-butyl-3- [4- [3- umutima mubi.Ikuraho atom iyode muri amiodarone kugirango igabanye uburozi bwa tiroyide nizindi ngingo;wongeyeho itsinda rya methylsulfonyl kuruhande rwa benzofuran kugirango ugabanye lipofilique, bityo bigabanya igice cyubuzima bwibiyobyabwenge kandi bigabanya ingaruka zo kwegeranya ingirabuzimafatizo hamwe nibishoboka byibiyobyabwenge bya neurotoxicity.Byombi muri Reta zunzubumwe za Amerika 2011 hamwe nu Burayi bwo mu mwaka wa 2010 bwa Atrial Fibrillation Guidelines birasaba dronedarone yo kuvura fibrillation atriel.Dronedarone ifite umutekano kandi ikora neza mukuvura igipimo cyumuyaga no gukomeza umuvuduko wa sinus kubarwayi batandukanye badafite AF ikabije.Irashobora kuba imiti ifatika yo gusimbuza amiodarone.Dronedarone irashobora kandi kugabanya urupfu rwabarwayi ba AF ndetse n’abarwayi ba AF bakomeje.Kubwibyo, byitezwe kuba imiti yumurongo wambere kubarwayi ba AF nta kunanirwa k'umutima gukabije.Byongeye kandi, gukoresha anticoagulants mu barwayi bafite ibyago byinshi byo hagati ya AF ni ingirakamaro mu gukoresha dronedarone.