Kugurisha Byinshi Kugurisha Ibrutinib Abahuza N-3 CAS 330792-70-6

Hamwe n'iyi nteruro, ubu twahindutse kuba mubishoboka cyane cyane guhanga udushya mu ikoranabuhanga, gukoresha amafaranga menshi, no guhatanira ibiciro kubicuruzwa byinshi bishyushye byo kugurisha Ibrutinib Intermediates N-3 CAS 330792-70-6, Dutegereje kuguha ibicuruzwa byacu mugihe cya vuba, kandi uzasanga ibyo twavuze bifite ishingiro kandi ubwiza bwibicuruzwa byacu nibyiza cyane!
Hamwe niyi nteruro mubitekerezo, ubu twahindutse kuba mubishoboka cyane cyane guhanga udushya mu ikoranabuhanga, gukoresha amafaranga menshi, no guhatanira ibiciro kuriUbushinwa Ibrutinib N-3 n'Abunzi, Kugeza ubu ibicuruzwa byacu byoherejwe mu burasirazuba bw’Uburayi, Uburasirazuba bwo hagati, Amajyepfo y’Amajyepfo, Afurika na Amerika yepfo n’ibindi. Dufite 13years yo kugurisha no kugura mu bice bya Isuzu mu gihugu ndetse no hanze yacyo ndetse no gutunga sisitemu igezweho ya elegitoroniki Isuzu igenzura.Twubaha umuyobozi wibanze wubunyangamugayo mubucuruzi, icyambere muri serivisi kandi tuzakora ibishoboka byose kugirango duhe abakiriya bacu ibicuruzwa byiza na serivisi nziza.

Hagati ya synthesis ya allopurinol.

Nimwe muma 3-amino-4 yasimbuwe na pyrazole.Irashobora gukoreshwa nkigihe cyo guhuza ibinyabuzima byinshi byifashishwa mu bya farumasi, nka allopurinol, kimwe mu bikomoka kuri pyrazolopyrimidine, icya nyuma kuva mu 1963 Kuva cyakoreshwa mu mavuriro, cyabaye imiti nyamukuru yo kuvura indwara ya goutte.Kugeza ubu, hari uburyo buke buzwi bwo guhuza

3-aminopyrazole-4-carboxamide hemisulfate mu Bushinwa, cyane cyane mugukora malononitrile na triethyl orthoformate kugirango bategure ethoxymethylene malononitrile, hanyuma hamwe na reaction ya hydrazine hydrat itanga 3-amino-4-cyanopyrazole, amaherezo ikabyara aside hamwe na sulfurike yibanze cyane.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin n'abandi 3-aminopyrazole- Synthesis ya 4-formamide hemisulfate [J]. Inganda zikora imiti, 2008, 6 (22): 39 40), umusaruro wose wa synthesis nubu buryo ni 60% (ubarwa nka malononitrile), ubu buryo burimo intambwe eshatu, reaction ni ndende, na reagent zikoreshwa, nka malononitrile na ethoxymethylene malononitrile, zifite uburozi kandi buhenze.Mubyongeyeho, 3-aminopyrazole-4 yateguwe nubu buryo -Formamide hemisulfate ifite ibara ritoroshye kuyikuramo kandi bisaba gutunganyirizwa hamwe, bigoye cyane.

Hari raporo mubuvanganzo bwamahanga ukoresheje pyridylamide hydrazone na ethoxymethylene malononitrile nkibikoresho fatizo kugirango ubone 3-amino-4-cyanopyrazole wongeyeho na cycleisation, hanyuma ukitwara hamwe na acide sulfurike yibanze kugirango ubone icyerekezo (Reuken G Jones. Ibisubizo bya orthoester hamwe na orthoester hamwe na orthoester hamwe na ifumbire mvaruganda [J]. J Am Chem Soc. 1952.74 (5): 4889 4891).Ibikoresho by'ibanze bikoreshwa muri ubu buryo bihenze, umusaruro wa reaction ntabwo ari mwinshi, kandi inyungu y’umusaruro w’inganda ni muto.Bigomba kuba bigoye.

Ubuyobozi bukuru:Ibipimo ngenderwaho
Inyuma:Ifu yera cyangwa umuhondo

Ipaki:25kg / ingoma
suzuma （HPLC） ibirimo Birarenze cyangwa bingana na 98.0%
ubuziranenge （HPLC） ibirimo Birarenze cyangwa bingana na 99.5%

JIN DUN Ubuvuzi bufiteImpamyabumenyi ya ISO kandi yujuje ubuziranenge bwa GMP, yakoresheje inzobere mu kuvura ibiyobyabwenge mu gihugu no mu mahanga bifite uburambe bukomeye bwo kuyobora R&D ya sosiyete.

TECHNOL OGY INYUNGU
Pressure Umuvuduko mwinshi Catalytic Hydrogenation.Umuvuduko mwinshi Hydrogenolysis reaction.Imyitwarire ya Cryogenic (<-78% C)
● Synthesis ya Aromatic Heterocyclic
Re reaction Kuvugurura
Res Igisubizo cya Chiral
Heck, Suzuki, Negishi, Sonogashira.Gignard

Ibikoresho

Laboratwari yacu ifite ibikoresho bitandukanye byo kugerageza no kugerageza, nka: NMR (Bruker 400M) 、 HPLC 、 chiral-HPLC 、 LC-MS 、 LC-MS / MS (API 4000) 、 IR 、 UV 、 GC 、 GC-MS, Chromatografiya, Microwave Synthesizer, Parallel Synthesizer, Calorimeter itandukanye (DSC), Electron Microscope…

Itsinda R&D

Ubuvuzi bwa Jindun bufite itsinda ryabakozi ba R&D babigize umwuga, kandi bukoresha impuguke nyinshi zo mu gihugu ndetse n’amahanga mu kuvura ibiyobyabwenge kugira ngo ziyobore R&D, bigatuma synthesis yacu neza kandi neza.

Twafashije amasosiyete menshi yimiti yimiti yo murugo, nkaHansoh, Hengrui na Pharm ya HEC.Hano tuzerekana igice cyabo.

Urubanza rwa Customzation Urubanza rwa mbere:

Cas No.: 110351-94-5

Urubanza rwa Customzation Urubanza rwa kabiri:

Cas No.: 144848-24-8

Urubanza rwa Customzation Urubanza rwa gatatu:

Cas No.: 200636-54-0

1.Hindura abahuza bashya cyangwa APIs.Kimwe nkuko byavuzwe haruguru kugabana, abakiriya bafite ibyo bakeneye kuri Intermediates cyangwa APIs, kandi ntibashobora kubona ibicuruzwa bikenewe kumasoko, noneho turashobora gufasha Customize.

2.Gutunganya neza ibicuruzwa bishaje.Itsinda ryacu rizafasha mugutezimbere no kunoza umusaruro nkuwo inzira ya reaction ishaje, igiciro cyumusaruro ni kinini, kandi imikorere ni mike.Turashobora gutanga ibyangombwa byuzuye byo guhererekanya ikoranabuhanga no kunoza imikorere, gufasha abakiriya kubyara umusaruro mwiza.

Kuva ibiyobyabwenge byibasiye INDs, JIN DUN Medical iraguhaumurongo umwe wihariye R&D ibisubizo.

JIN DUN Ubuvuzi bushimangira gushinga itsinda rifite inzozi, gukora ibicuruzwa byiyubashye, byitondewe, bikomeye, kandi byose kugirango ube umufatanyabikorwa wizewe ninshuti yabakiriya!

Hamwe n'iyi nteruro, ubu twahindutse kuba mubishoboka cyane cyane guhanga udushya mu ikoranabuhanga, gukoresha amafaranga menshi, no guhatanira ibiciro kubicuruzwa byinshi bishyushye byo kugurisha Ibrutinib Intermediates N-3 CAS 330792-70-6, Dutegereje kuguha ibicuruzwa byacu mugihe cya vuba, kandi uzasanga ibyo twavuze bifite ishingiro kandi ubwiza bwibicuruzwa byacu nibyiza cyane!
Ibicuruzwa byinshiUbushinwa Ibrutinib N-3 n'Abunzi, Kugeza ubu ibicuruzwa byacu byoherejwe mu burasirazuba bw’Uburayi, Uburasirazuba bwo hagati, Amajyepfo y’Amajyepfo, Afurika na Amerika yepfo n’ibindi. Dufite 13years yo kugurisha no kugura mu bice bya Isuzu mu gihugu ndetse no hanze yacyo ndetse no gutunga sisitemu igezweho ya elegitoroniki Isuzu igenzura.Twubaha umuyobozi wibanze wubunyangamugayo mubucuruzi, icyambere muri serivisi kandi tuzakora ibishoboka byose kugirango duhe abakiriya bacu ibicuruzwa byiza na serivisi nziza.