Igiciro Urutonde rwibintu byiza birwanya virusi ya Entecavir CAS 142217-69-4 hamwe nigiciro cyiza

Turerekana kandi ibicuruzwa cyangwa serivisi biva hamwe nibigo bihuza indege.Dufite ishami ryacu ryo gukora hamwe n'ibiro bishinzwe amasoko.Turashobora kuguha byoroshye uburyo bwose bwibicuruzwa bisa nibicuruzwa byacu bitandukanye kubiciro Urutonde rwibiciro byiza bya Antiviral Entecavir Powder CAS 142217-69-4 hamwe nigiciro cyiza, Tugiye guhora duharanira kongera uruganda rwacu no gutanga ibicuruzwa byiza byiza. hamwe n'ibiciro bikaze.Ikibazo cyangwa igitekerezo icyo aricyo cyose kirashimirwa cyane.Wibuke kudufata mu bwisanzure.
Turerekana kandi ibicuruzwa cyangwa serivisi biva hamwe nibigo bihuza indege.Dufite ishami ryacu ryo gukora hamwe n'ibiro bishinzwe amasoko.Turashobora kuguha byoroshye uburyo bwose bwibicuruzwa bisa nibicuruzwa byacu bitandukanyeUbushinwa Entecavir na 142217-69-4, Twakiriye neza abakiriya bo murugo no mumahanga gusura isosiyete yacu no kuganira mubucuruzi.Isosiyete yacu ihora ishimangira ku ihame rya "ubuziranenge bwiza, igiciro cyiza, serivisi yo mu rwego rwa mbere".Twiteguye kubaka ubufatanye burambye, bwinshuti kandi bwungurana ibitekerezo nawe.

Entecavir （SQ 34676;BMS 200475） ihitamo kandi ikora HBV Inhibitor.Muri HepG2 selile EC50 agaciro ni 3.75 nM.Imiti igabanya ubukana bwa hepatite B n'imiti igabanya ubukana bwa mbere.

Ingaruka ya Entecavir

Iki gicuruzwa nikigereranyo cya guanine nucleoside, kigira ingaruka mbi kuri virusi ya hepatite B (HBV) polymerase.Irashobora kuba fosifora muri triphosifate ikora, kandi igice cya kabiri cyubuzima bwa triphosifate mungirangingo ni amasaha 15.Muguhangana na HBV polymerase isanzwe ya substrate deoxyguanosine triphosphate, entecavir triphosphate irashobora guhagarika ibikorwa byose uko ari bitatu bya virusi polymerase (reverse transcriptase): (1) Gutangiza polymerase ya HBV;(2) pregenomic mRNA Imiterere yumurongo mubi wo kwandukura inyandiko;(3) Synthesis yumurongo mwiza wa ADN ya HBV.Guhagarika inhibitori (Ki) ya entecavir triphosphate kuri HBV ADN polymerase ni 0.0012μM.Entecavir triphosphate igira ingaruka mbi zo guhagarika ingirabuzimafatizo α, β, δ ADN polymerase na mitochondrial γ ADN polymerase, ifite agaciro ka 18 kugeza 160 μM.

Imiterere yumubiri na chimique ya Entecavir

Gasutamo ya Entecavir

Andi makuru:

Qu Qiang (PhD muri farumasi y’ubuvuzi, Ishami rya Farumasi, Ibitaro bya Xiangya, Kaminuza Nkuru y’Amajyepfo) na Wang Ruoguang (Umuganga w’Ubuvuzi, impamyabumenyi y'ikirenga muri biologiya, Ikigo cy’ubushakashatsi cy’ubuvuzi cya Changsha Ruoguang) na bo banditse ko: muri gahunda ya entecavir, entecavir ishobora gufatwa imyaka myinshi cyangwa imyaka 10.Kurenza imyaka.Kandi irashobora gukoreshwa nabagore batwite, ikerekana umutekano mwiza.

Urebye kuri ubwo buryo buzwi bwa farumasi ya farumasi, Entecavir irashobora kugira ingaruka nini ya virusi ya virusi, ntabwo ikora neza kuri HBV.

Dukunze kandi gukoresha Entecavir kugirango tuvure indwara zandurira mu myanya y'ubuhumekero ku ivuriro, kandi ingaruka ziratangaje.

Kugeza ubu, mu isesengura ryihuse ry’abarwayi barenga 500 COVID19 i Hubei (ahantu), umuntu umwe gusa ni we wafashe entecavir.Igihe cyo kwandikirwa cyari mu ntangiriro za Mutarama, hanyuma ibiyobyabwenge birahagarara.

Mugihe utera inkunga abaganga i Hubei, abaganga bamwe bo mu nzego z'ibanze, cyangwa amatsinda afite ibyago byinshi, kuri ubu bakoresha Entecavir mu gukumira COVID19, nta kibazo cyanduye.Abantu bakekwa gufata entecavir, ntamuntu wigeze atera imbere ngo asuzumwe na COVID19.

Ibibazo by'ipatanti:

Hariho inzira ebyiri, inzira 06 na 89 inzira.Iherezo rya patenti kubikorwa 06 ni kare cyane (birangira muri 2023)!Nubwo ikiguzi cyibikorwa ari gito, ireme ni ryiza, kandi abakozi barashobora gukomera, inama zabo bwite: Kubihingwa byimiti, koresha inzira ya 06 kugirango utirata cyane;kubigo bikorerwamo ibya farumasi, ntugafate fluke kandi ntugire ibyago byinshi.

Muri 2014, Chia Tai Tianqing yageze ku mwaka kugurisha miriyari 10 z'amadorari yishingikirije ku biyobyabwenge rusange nka entecavir, muri byo entecavir ikaba yari 20%.

Kuva entecavir yemerewe gutumizwa mu 2005, amasosiyete arenga 100 y’imiti yo mu gihugu yasabye kwandikisha ibicuruzwa;muri byo, amasosiyete yemewe yemewe arimo Jiangsu Zhengda Tianqing Pharmaceutical (yigana bwa mbere), Pharmaceutical ya Hainan Zhonghe, na Pharmaceutical Co., Fujian Guangxi Pharmaceutical Co., Ltd. Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Ibinyabuzima.

Imiti, Anhui Baker Biopharmaceutical, Uruganda rwa Farumasi ya Hunan Concord, Uruganda rukora imiti rwa Beijing Xiehe, Imiti ya Beijing Baiao, Pharmaceutical Xinlitai, Dongyangguang, nibindi.;kure guhera umunsi amasezerano yagenwe, iki gicuruzwa cyinjiye murwego rwamoko yatangajwe kuva 2007.

Turerekana kandi ibicuruzwa cyangwa serivisi biva hamwe nibigo bihuza indege.Dufite ishami ryacu ryo gukora hamwe n'ibiro bishinzwe amasoko.Turashobora kuguha byoroshye uburyo bwose bwibicuruzwa bisa nibicuruzwa byacu bitandukanye kubiciro Urutonde rwibiciro byiza bya Antiviral Entecavir Powder CAS 142217-69-4 hamwe nigiciro cyiza, Tugiye guhora duharanira kongera uruganda rwacu no gutanga ibicuruzwa byiza byiza. hamwe n'ibiciro bikaze.Ikibazo cyangwa igitekerezo icyo aricyo cyose kirashimirwa cyane.Wibuke kudufata mu bwisanzure.
UrutondeUbushinwa Entecavir na 142217-69-4, Twakiriye neza abakiriya bo murugo no mumahanga gusura isosiyete yacu no kuganira mubucuruzi.Isosiyete yacu ihora ishimangira ku ihame rya "ubuziranenge bwiza, igiciro cyiza, serivisi yo mu rwego rwa mbere".Twiteguye kubaka ubufatanye burambye, bwinshuti kandi bwungurana ibitekerezo nawe.