Ibihumbi by'amadolari ya COVID-19 imiti rusange yo mu Buhinde yagurishijwe?reba hanze!

1.Ibihumbi by'amadolari ya COVID-19 imiti rusange yo mu Buhinde yagurishijwe?reba hanze!

Vuba aha, ingingo ivuga kuri "COVID-19 imiti rusange yo mu Buhinde yagurishijwe ibihumbi by'amadorari mu isanduku" yagaragaye ku rutonde rw’ishakisha rya microblog.Imiti imwe n'imwe yaguzwe mu izina ry’Ubushinwa News Network, kandi ububiko bwari bwaragurishijwe, bityo byabaye ngombwa ko tubibika icyumweru mbere.Abaganga baributsa ko ibiyobyabwenge bitagomba kugurwa hakoreshejwe inzira zidasanzwe.Byongeye kandi, amatsinda adafite ibyago byinshi ntabwo akeneye gukoresha imiti yo mu kanwa ya COVID-19.

Igiciro cyambere cyisanduku yibiyobyabwenge ni 2300, naho kugura mubuhinde ni 1600

“Ubu amabwiriza yanditse neza.”Abakozi benshi bagura ibiyobyabwenge mubuhinde babwiye chinanews.com ko imiti yabo ya Pfizer COVID-19 yo mu kanwa imiti ya Paxlovid yagurishijwe vuba aha.Bibaye ngombwa, barashobora kubanza kwishyura kubitsa gusa, kandi ibicuruzwa birashobora gutangwa mugihe cyicyumweru kare, cyangwa ukwezi gutaha.

Niba amagambo "COVID-19 Ubuhinde", "COVID-19 ibiyobyabwenge rusange" nibindi byinjijwe kurubuga rwa e-ubucuruzi, abaguzi barashobora kubona vuba amakuru yabakozi bagura, ariko muri rusange basaba kongeramo inshuti za WeChat, kandi hanyuma menyesha ibicuruzwa byihariye amakuru nibisabwa.

Imiti rusange ya Paxlovid yagurishijwe naba agent harimo Primovir mubipfunyika icyatsi na Paxista mubipfunyika ubururu.Iyambere ikorwa na Astrica, isosiyete yo mu Buhinde, naho iyanyuma ikorwa na Azista, ishami ry’imiti y’imiti yo mu Buhinde Hetero.Kugeza ubu, Primovir hamwe nudupapuro twatsi twahagaritse umusaruro, kandi Paxista yonyine ifite ipaki yubururu iracyagurishwa.

Umukozi umwe yerekanye ko igiciro cy’iposita yo mu gihugu cyari 1600 yu gasanduku, naho ayohereza mu mahanga yoherejwe ni 1200 ku gasanduku, 400 bihendutse.Igiciro cya Paxlovid mubushinwa ni 2300 yu gasanduku.

Iyi miti rusange iragoye kugura mububiko muri iki gihe.Ukurikije kugura kwavuzwe haruguru, kubika biremewe, kandi ubutumwa bwoherejwe nu Buhinde buzagera mu Bushinwa mu minsi 15-20.Yasabye kandi ko buri muntu ashobora kugura udusanduku 2 gusa.

Abaganga baributsa: Biragoye kuvuga ukuri uhereye kubinyoma.Komeza kuba maso

Mubyukuri, Paxlovid imaze igihe kinini ikoreshwa mu kuvura indwara ya COVID-19 mu Bushinwa, ariko ikoreshwa cyane mu bitaro bimwe na bimwe byagenwe kandi bisaba uruhushya rw’abaganga.Ibitaro byose ntabwo bifite ibiyobyabwenge.

Birakwiye ko tumenya ko imiti rusange igurishwa hashingiwe kuri komisiyo irashobora kugurwa hatabayeho no kwandikirwa.Ni muri urwo rwego, abaganga babigize umwuga baributsa abantu bose kuba maso.

Ati: "Nka baganga babigize umwuga, ntabwo dushyigikiye kugura kwigana abanyamahanga, kuko bigoye kuvuga ukuri bivuye mu binyoma."Zhang Jiming, umuyobozi wungirije w'ikigo cy’ubuvuzi cy’indwara zandura n’umuganga mukuru, umwarimu akaba n’umugenzuzi w’umuganga w’ibitaro bya Huashan bishamikiye kuri kaminuza ya Fudan, yabwiye chinanews.com ko bamwe mubarwayi yabajije cyangwa imiryango yabo baguze kwigana wenyine, kandi bafite impungenge ko bagura ibiyobyabwenge byimpimbano.Yavuze ko bigoye kwemeza ireme ry'ibiyobyabwenge rusange biva aho bituruka ndetse no kubungabunga imiti igihe ugura imiti rusange ivuye mu mahanga.

Zhang Jiming yavuze ko imiti yo mu kanwa ya COVID-19 ikoreshwa cyane cyane mu matsinda afite ibyago byinshi byo kwirinda indwara zikomeye, kandi ishobora kugira akamaro gusa iyo ikoreshejwe hakiri kare.Amatsinda adafite ibyago byinshi ntabwo akeneye kwihutira kugura, kandi gukoresha nabi bishobora gutera ibiyobyabwenge.Ntabwo kandi ari ngombwa mubuvuzi, kubera ko abarwayi benshi badafite ibimenyetso cyangwa byoroheje, kandi inzira yindwara iba yonyine.

Yabwiye chinanews.com ko, kubijyanye n’ibibera muri Shanghai, ibitaro bikuru, ibitaro byagenwe na COVID-19 n’ibindi bigo by’ubuvuzi muri rusange bifite umubare munini w’ibiyobyabwenge birwanya COVID-19, bikoreshwa n’amatsinda menshi ashobora guhura n’ibimenyetso kandi aribyo yanduye COVID-19, mu rwego rwo gukumira indwara zikomeye no kugabanya impfu.

Byongeye kandi, nk'uko bitangazwa n'ibitangazamakuru, abashinzwe amategeko bibutsa ko imiti rusange yo mu Buhinde COVID-19 igurishwa ku rubuga rwa interineti itaremerwa mu Bushinwa.Muri iri tegeko rigenga imiyoborere y’ibiyobyabwenge muri Repubulika y’Ubushinwa, nubwo ibiyobyabwenge byashyizwe ku rutonde mu mahanga ariko bikaba bitemewe mu Bushinwa bitakigaragara gusa ko ari ibiyobyabwenge by’impimbano, ababikora bazakomeza guhanwa n’ubuyobozi kubera kwinjiza ibiyobyabwenge mu buryo butemewe.

2.Xinlitai yagiye!Gufata ubwoko bubiri bwa miliyari 1, ubwoko 11 bwimiti yo mucyiciro cya mbere.

Vuba aha, umuyoboro wa Xinlitai R&D wateye imbere.Icyiciro cya 1 imiti mishya SAL0133 ibinini byakoreshejwe mugukoresha amavuriro.Ibisubizo byisesengura ryibarurishamibare byabonetse mu cyiciro cya Phase Ib ivura rya PCSK9 antibody ya monoclonal.Kuva mu 2022, Xinlitai yasabye IND / NDA imiti 7 igezweho, kandi ubushakashatsi n’iterambere byatejwe imbere.Kugeza ubu, Xinlitai ifite ubwoko bubiri bwa miliyari 1 z'urwego, 22 muri zo zarasuzumwe (8 nizo zambere);Ibiyobyabwenge 21 bishya birimo gukorwa ubushakashatsi, 6 muri byo biri mubyiciro byubuvuzi bya NDA cyangwa Icyiciro cya III, kandi umuyoboro wo guhanga udushya winjiye mugihe cyamafaranga.

Umuyoboro mugari COVID-19 Ubuvuzi bwo mu kanwa buragaragara!Xinlitai Yinjira muri COVID-19

Ku ya 20 Ukuboza, Xinlitai yatangaje ko ikoreshwa ry’ivuriro rya SAL0133, imiti ntoya ya molekile y’udushya twakozwe na sosiyete yigenga, ryemewe n’ikigo cya Leta gishinzwe ibiribwa n’ibiyobyabwenge.SAL0133 ni imbaraga zikomeye, zagutse zirwanya anti coronavirus 3CL protease (3CLpro) inhibitor yigenga kandi yatejwe imbere nisosiyete ifite uburenganzira bwubwenge bwigenga.Kugeza ubu, ibimenyetso byerekana ivuriro bigomba gutezwa imbere ni ukuvura abantu bakuru boroheje / basanzwe banditse coronavirus pneumonia (COVID-19).

3CLpro igira uruhare runini mugusubiramo RNA ya coronavirus yubuvanganzo, cyane cyane mugice cyambere cyo kwigana nyuma yuko virusi yinjiye muri selile yakiriye, ikabuza ibikorwa bya protease ya 3CLpro, ishobora guhagarika neza kwandura virusi no kugera ku ruhare rwo kurwanya coronavirus.

SAL0133 ifite uburyo busobanutse bwibikorwa, kandi ifite imbaraga, nini-nini ya anti-COVID-19.Biteganijwe ko bidakenewe guhuza na CYP3A4 inhibitor ritonavir, kandi ibyago bishobora guhura nibiyobyabwenge ni bike;Biteganijwe ko hazageraho imiti imwe ivura imiti rimwe kumunsi no kunoza imiti y’abarwayi.Niba ishobora gutezwa imbere no kwemezwa kubucuruzi, izaha abarwayi amahitamo mashya kugirango babone ibyo bakeneye bitavurwa.

Ubushakashatsi niterambere ryibikorwa bya 3CL birwanya imiti ya molekile yo mu kanwa ya COVID-19 yakunzwe cyane.Kugeza ubu, Paxlovid ya Pfizer yonyine niyo yemerewe kwamamaza ku isi.Ibigo by’imiti birenga 10 byo mu rugo n’ibigo by’ubushakashatsi mu bya siyansi byagiye bikora ubushakashatsi n’iterambere ry’imiti ya 3CL irwanya COVID-19, harimo FB2001 ya Frontier Biology, VV993 ya Biologiya ya Junshi / Wangshan Wangshui, SIM0417 ya Pioneer Pharmaceutical, ibinini bya RAY1216 bya farumasi ya Zhongsheng, GST-HG171 ya Guangshengtang, nibindi

Hamwe na miliyari 2 zingenzi zamoko, ibiyobyabwenge 7 bishya muri uyu mwaka byakira iterambere rishya

Ahagana mu mpera z'umwaka wa 2022, nk'umuntu uhagarariye impinduka za R&D mu nganda zimiti, Xinlitai yabonye inzira yiterambere ryayo idasanzwe mu gihe cy'igitutu no guhinduka.

Mu gihembwe cya mbere cya 2022, amafaranga y’isosiyete yinjije miliyari 2,548, aho umwaka ushize wazamutseho 16.5%, naho inyungu zayo zikaba miliyoni 539, aho umwaka ushize wiyongereyeho 37.64%.Imikorere myiza yashyizeho urufatiro rukomeye rwiterambere.Isosiyete iteganya ko mu 2022, Taijia (ibinini bya clopidogrel bisulfate) izinjiza hafi miliyari imwe, naho Sinritan (ibinini bya alisartan) izinjiza hafi miliyoni 900 kugeza kuri miliyari imwe.Isosiyete ifite amoko 22, 8 muri yo akaba ari yo ya mbere mu Bushinwa.

Muri 2019, ubwoko nyamukuru bwa Xinlitai, Taijia, bwatakaje isoko mu kugura 4 + 7 ubumwe bwaguzwe hagati, bituma Xinlitai agira icyo ahindura.Muri raporo ngarukamwaka ya 2019, Xinlitai yatangaje ko "umuyoboro w'ubushakashatsi uzashyirwa mu bikorwa mu buryo bunoze, kandi umushinga wo kurwanya ibibyimba birwanya ibibyimba ndetse n'imishinga ya antibiotike mu byiciro bimwe na bimwe bizarangira".Muri 2020, mu rwego rwo kurushaho kunoza umuyoboro uri gukorwaho ubushakashatsi no kwibanda kuri R&D no guteza imbere ibicuruzwa bishya, Xinlitai yimuye uburenganzira n’inyungu bijyanye na hydrochloride ya dapoxetine, hydrochloride ya erlotinib, rivasaban n’indi mishinga, maze ahabwa amafaranga yo kohereza.

Nyuma yo kugira ibyo uhindura, kuri ubu, umuyoboro rusange w’ibiyobyabwenge bya Xinritai ufite gusa icyiciro cya 4 cyo kwamamaza cyo kwigana ibinini bya sodium ya Sakubatrovalsartan irimo gusuzumwa, hamwe n’inyongera yo gusuzuma isuzuma rihoraho rya sodium ya cefuroxime yo gutera inshinge na sodium ya cefotaxime yo gutera inshinge.Twabibutsa ko kuva muri Nyakanga 2019, Xinlitai atigeze asaba imiti mishya mu myaka irenga 3, kandi yibanda cyane ku guhanga udushya n’ubushakashatsi.

Kuva mu 2022, Xinlitai yagiye atera imbere mu bushakashatsi no guteza imbere ibiyobyabwenge bishya.Ku ya 4 Mutarama 2022, gusaba urutonde rwa HIF-PHI inhibitor ya CINRITAI ibinini bya Enasitar byakozwe na CDE;Nyuma, Isosiyete yatanze ibyifuzo byubuvuzi kumiti itanu mishya yo mucyiciro cya 1, aribyo, recombinant human neuromodulin-1 anti HER3 antibody fusion protein, ibinini bya SAL0112, inshinge za SAL008, ibinini bya SAL0119 na tableti ya SAL0133;Ku ya 3 Ugushyingo, icyiciro gishya 2.3 cyateje imbere ibinini bya alisartan na amlodipine ya SINRITAI yatanze icyifuzo cyo kurutonde, bikaba biteganijwe ko bizashyiraho ingamba zifatika hamwe n’icyiciro cya 1.1 imiti igabanya ubukana bwa SINRITAI.

Ubuvuzi bwa JinDunifite ubufatanye burambye bwubushakashatsi nubushakashatsi hamwe na tekinoroji yo muri kaminuza zo mu Bushinwa.Hamwe n'ubuvuzi bukomeye bwa Jiangsu, bufitanye umubano w'igihe kirekire n'Ubuhinde, Aziya y'Amajyepfo y'Uburasirazuba, Koreya y'Epfo, Ubuyapani n'andi masoko.Itanga kandi isoko ryisoko nogurisha mubikorwa byose kuva hagati kugeza ibicuruzwa byarangiye API.Koresha ibikoresho byegeranijwe bya Yangshi Chemical muri chimie ya fluor kugirango utange serivisi zidasanzwe zo gutunganya imiti kubafatanyabikorwa.Tanga uburyo bushya bwo gukora no gukora ubushakashatsi bwanduye kubakiriya.

Ubuvuzi bwa JinDun bushimangira gushinga itsinda rifite inzozi, gukora ibicuruzwa byiyubashye, byitondewe, bikomeye, kandi byose bigasohoka kugirango ube umufatanyabikorwa wizewe ninshuti yabakiriya! Umwe mubatanga ibisubizo bihagarika ibisubizo, R&D yihariye hamwe na serivise zitanga umusaruro kubunzi ba farumasi na APIs, abahangaumusaruro wimiti yihariye(CMO) hamwe na farumasi yihariye ya R&D hamwe nabatanga serivisi (CDMO).Jindun azaguherekeza gukoresha COVID-19.