• NEBANNER

“Kamere” yasohoye inyandiko igaragaza imikorere ya “switch switch” y'ingenzi ya bariyeri y'amaraso n'ubwonko

Kuri iki cyumweru, ikinyamakuru cyo hejuru cy’inyigisho cyitwa Nature cyasohoye urupapuro rw’ubushakashatsi ku rubuga rw’itsinda rya Porofeseri Feng Liang muri kaminuza ya Stanford, rugaragaza imiterere n’uburyo bukoreshwa mu maraso y’ubwonko bw’amaraso ubwonko bwa lipide itwara poroteyine MFSD2A.Ubu buvumbuzi bufasha gukora ibiyobyabwenge kugirango bigabanye ubwonko bwamaraso n'ubwonko.

CWQD

MFSD2A ni transport ya fosifolipide ishinzwe gufata aside ya dososahexaenoic mu bwonko mu ngirabuzimafatizo ya endoteliyale igizwe n'inzitizi y'amaraso n'ubwonko.Acide ya Docosahexaenoic izwi cyane nka DHA, ikenewe mu mikurire n'imikorere y'ubwonko.Guhinduka bigira ingaruka kumikorere ya MFSD2A birashobora gutera ikibazo cyiterambere cyitwa syndrome ya microcephaly.

Ubushobozi bwo gutwara lipide ya MFSD2A busobanura kandi ko iyi poroteyine ifitanye isano rya bugufi nubusugire bwinzitizi yubwonko bwamaraso.Ubushakashatsi bwibanze bwerekanye ko igihe ibikorwa byayo bigabanutse, inzitizi yamaraso-ubwonko izatemba.Kubwibyo, MFSD2A ifatwa nkicyizere cyo kugenzura ibintu mugihe bibaye ngombwa kurenga inzitizi yubwonko bwamaraso kugirango itange imiti ivura mubwonko.

Muri ubu bushakashatsi, itsinda rya Porofeseri Feng Liang ryifashishije ikoranabuhanga rya cryo-electron microscopi kugira ngo ribone imiterere ihanitse y’imbeba MFSD2A, igaragaza imiterere yihariye idasanzwe idasanzwe hamwe na cavite ihuza umwobo.

Hamwe no gusesengura imikorere hamwe no kwigana imbaraga za molekuline, abashakashatsi berekanye kandi ibibanza bya sodium byabitswe mu miterere ya MFSD2A, bagaragaza inzira zishobora kwinjira muri lipide, no gufasha gusobanukirwa n'impamvu ihinduka rya MFSD2A ritera syndrome ya microcephaly.

VSDW

Igihe cyo kohereza: Nzeri-01-2021