Guanosine

Guanosine ikoreshwa nkigihe cya Valaciclovir.
Valacyclovir numuti wa guanine analogue.Ikoreshwa mubuvuzi bwa herpes simplex na herpes zoster kwandura indwara zandurira mu mibonano mpuzabitsina.Ibicuruzwa nibibanziriza acyclovir.Yinjira vuba nyuma yubuyobozi bwo munwa kandi ihinduka vuba acyclovir mumubiri.Ingaruka zayo za virusi ikinwa na acyclovir.Nyuma ya acyclovir yinjiye mu ngirabuzimafatizo zanduye, irushanwa na deoxynucleoside ya virusi thymidine deoxynucleoside kinase cyangwa selile kinase, kandi imiti ikaba fosifori mu buryo bwa acilique guanosine triphosphate.Nka substrate yo kwigana virusi, acyclovir irushanwa na deoxyguanine triphosphate ya virusi ya polymerase ya virusi, ibuza virusi ya ADN kandi ikerekana ingaruka za virusi.Ibikorwa bya virusi yibicuruzwa muri vivo birutwa na acyclovir, kandi igipimo cyo kuvura virusi ya herpes simplex virusi ya I nubwoko bwa II ni 42,91% na 30.13% hejuru ya acyclovir.Ifite kandi ingaruka zikomeye zo kuvura virusi ya varicella zoster.