8-Bromo-7-ariko-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3
8-Bromo-7-ariko-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3
Koresha:Hagati ya Linagliptin.
Koresha ：Hagati ya Linagliptin
Ibipimo ngenderwaho ：urwego rwumushinga
Suzuma ：98-102%
Inyuma ：Ifu yera kugeza yoroheje
Ipaki:25kg / ingoma
Gusesengura linagliptine iriho hamwe nurufunguzo rwayo hagati ya 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1 - [(4-methyl -2-quinazolinyl) methyl) -1H-purine- Uburyo bwa 2,6-dione (11) synthesis, shakisha inzira yubukorikori ikwiranye ninganda.Uburyo: vuga muri make inzira zitandukanye.Ibisubizo n'imyanzuro: Inzira 2.2 ifite inzira yoroheje ugereranije nigiciro gito, ikwiranye ninganda zinganda.
8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione ni intera nyamukuru hagati muguhuza imiti ya hypoglycemic linagliptin.Synthesis ya 1 ikoresha methyl urea na acide cyanoacetic nkibikoresho byo gutangira, kandi ikagira intambwe esheshatu ziterwa na kondegene, cycleisation, nitrosation, kugabanuka, cycleisation, na bromine hamwe numusaruro wa 46.3%.Imiterere yabahuza bose yemejwe na 1HNMR.
Ubuvumbuzi bwa none bujyanye nuburyo bworoshye bwo gutegura bwa linagliptin.Quinazoline, urufunguzo rwagateganyo rwo gutegura inkono imwe yo gutegura linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, intera itandukanijwe na kuyungurura, hanyuma yitwara hamwe na (R) 3 aminopiperidine dihydrochloride kugirango ubone igisubizo kirimo linagliptine.Nyuma yumuti urimo linagliptin yongeye gutunganywa, Deliraliptin ibicuruzwa byiza.Gutegura urufunguzo rwibanze hagati yubuvumbuzi bwakoresheje uburyo bumwe, bworoshye gukora kandi butezimbere umusaruro.Nyuma yurufunguzo rwibanze rumaze gutandukana, rusubizwa hamwe na (R) 3 aminopiperidine dihydrochloride, bityo Kubona linagliptine yera cyane kandi yujuje ibyangombwa bisabwa kugirango habeho umusaruro no kumenyekanisha ibigo bikorerwamo ibya farumasi.
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TECHNOL OGY INYUNGU
Pressure Umuvuduko mwinshi Catalytic Hydrogenation.Umuvuduko mwinshi Hydrogenolysis reaction.Imyitwarire ya Cryogenic (<-78% C)
● Synthesis ya Aromatic Heterocyclic
Re reaction Kuvugurura
Res Igisubizo cya Chiral
Heck, Suzuki, Negishi, Sonogashira.Gignard
Ibikoresho
Laboratwari yacu ifite ibikoresho bitandukanye byo kugerageza no kugerageza, nka: NMR (Bruker 400M) 、 HPLC 、 chiral-HPLC 、 LC-MS 、 LC-MS / MS (API 4000) 、 IR 、 UV 、 GC 、 GC-MS, Chromatografiya, Microwave Synthesizer, Parallel Synthesizer, Calorimeter itandukanye (DSC), Electron Microscope ...
Itsinda R&D
Ubuvuzi bwa Jindun bufite itsinda ryabakozi ba R&D babigize umwuga, kandi bukoresha impuguke nyinshi zo mu gihugu ndetse n’amahanga mu kuvura ibiyobyabwenge kugira ngo ziyobore R&D, bigatuma synthesis yacu neza kandi neza.
Twafashije amasosiyete menshi yimiti yimiti yo murugo, nkaHansoh, Hengrui na Pharm ya HEC.Hano tuzerekana igice cyabo.
Urubanza rwa Customzation Urubanza rwa mbere:
Cas No.: 110351-94-5
Urubanza rwa Customzation Urubanza rwa kabiri:
Cas No.: 144848-24-8
Urubanza rwa Customzation Urubanza rwa gatatu:
Cas No.: 200636-54-0
1.Hindura abahuza bashya cyangwa APIs.Kimwe nkuko byavuzwe haruguru kugabana, abakiriya bafite ibyo bakeneye kuri Intermediates cyangwa APIs, kandi ntibashobora kubona ibicuruzwa bikenewe kumasoko, noneho turashobora gufasha Customize.
2.Gutunganya neza ibicuruzwa bishaje.Itsinda ryacu rizafasha mugutezimbere no kunoza umusaruro nkuwo inzira ya reaction ishaje, igiciro cyumusaruro ni kinini, kandi imikorere ni mike.Turashobora gutanga ibyangombwa byuzuye byo guhererekanya ikoranabuhanga no kunoza imikorere, gufasha abakiriya kubyara umusaruro mwiza.
Kuva ibiyobyabwenge byibasiye INDs, JIN DUN Medical iraguhaumurongo umwe wihariye R&D ibisubizo.
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