3-Amino-4-pyrazole karbosamide hemisulfate

Hagati ya synthesis ya allopurinol.

Nimwe muma 3-amino-4 yasimbuwe na pyrazole.Irashobora gukoreshwa nkigihe cyo guhuza ibinyabuzima byinshi byifashishwa mu bya farumasi, nka allopurinol, kimwe mu bikomoka kuri pyrazolopyrimidine, icya nyuma kuva mu 1963 Kuva cyakoreshwa mu mavuriro, cyabaye imiti nyamukuru yo kuvura indwara ya goutte.Kugeza ubu, hari uburyo buke buzwi bwo guhuza

3-aminopyrazole-4-carboxamide hemisulfate mu Bushinwa, cyane cyane mugukora malononitrile na triethyl orthoformate kugirango bategure ethoxymethylene malononitrile, hanyuma hamwe na reaction ya hydrazine hydrat itanga 3-amino-4-cyanopyrazole, amaherezo ikabyara aside hamwe na sulfurike yibanze cyane.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin n'abandi 3-aminopyrazole- Synthesis ya 4-formamide hemisulfate [J]. Inganda zikora imiti, 2008, 6 (22): 39 40), umusaruro wose wa synthesis nubu buryo ni 60% (ubarwa nka malononitrile), ubu buryo burimo intambwe eshatu, reaction ni ndende, na reagent zikoreshwa, nka malononitrile na ethoxymethylene malononitrile, zifite uburozi kandi buhenze.Mubyongeyeho, 3-aminopyrazole-4 yateguwe nubu buryo -Formamide hemisulfate ifite ibara ritoroshye kuyikuramo kandi bisaba gutunganyirizwa hamwe, bigoye cyane.

Hari raporo mubuvanganzo bwamahanga ukoresheje pyridylamide hydrazone na ethoxymethylene malononitrile nkibikoresho fatizo kugirango ubone 3-amino-4-cyanopyrazole wongeyeho na cycleisation, hanyuma ukitwara hamwe na acide sulfurike yibanze kugirango ubone icyerekezo (Reuken G Jones. Ibisubizo bya orthoester hamwe na orthoester hamwe na orthoester hamwe na ifumbire mvaruganda [J]. J Am Chem Soc. 1952.74 (5): 4889 4891).Ibikoresho by'ibanze bikoreshwa muri ubu buryo bihenze, umusaruro wa reaction ntabwo ari mwinshi, kandi inyungu y’umusaruro w’inganda ni muto.Bigomba kuba bigoye.